Characterization of the hepatic microsomal mixed-function oxidase enzyme system in miniature pigs.
نویسندگان
چکیده
Hepatic microsomal protein, cytochrome P-450, UDP-glucuronyltransferase, ethylmorphine demethylase, aniline hydroxylase, and aryl hydrocarbon hydroxylase levels were measured in the 2-, 4-, 5-, 6-, and 8-month-old Hanford miniature pig. The activities or concentrations of all of the liver parameters measured had apparently reached their adult plateau level by 2 months of age. The use of the miniature pig in toxicology research programs is discussed.
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عنوان ژورنال:
- Drug metabolism and disposition: the biological fate of chemicals
دوره 4 1 شماره
صفحات -
تاریخ انتشار 1976